51 WGS 1KG dataset

• 51 WGS samples from 1000 Genomes Project

  • 19 725 105 unique variants
  • ~51×19×10⁶ = ~1×10⁹ genotypes

• Memory, disk, and start up time footprints

  • On disk: 1.1 GiB
  • RAM footprint in running cluster: ~ 1.7 GiB
  • Cluster start up time on a single node (laptop): t = 4.6 sec
  • Cluster memory and disk footprints slightly vary depending on number of nodes

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2890 WGS dataset

• 2890 WGS samples

  • ~86×10⁶ unique variants
  • ~2890×86×10⁶ = 2.48×10¹¹ total number of all genotypes
  • VEP annotated

• Memory, disk footprints

  • On disk: 29 GiB
  • RAM footprint in running k8s cluster with 4 pods: ~ 48.6 GiB
  • Cluster memory and disk footprints slightly vary depending on number of nodes

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76 156 WGS gnomAD

• gnomAD v3.1

  • 76 156 WGS samples
  • ~759×10⁶ unique variants
  • 415.071703278×10⁹ non-reference (hom+het) genotypes, modelled by HWE with 0.005 no-call rate
  • ~57.802404×10¹² total number of genotypes (with homozygous reference and missed genotypes = 76156*759×10⁶)

• Memory, disk, and start up time footprints

  • On disk: 312 GiB
  • RAM footprint in running cluster: 450 GiB
  • Cluster start up time on a single node (testbed): t = 260 sec
  • Cluster start up time on N nodes = t / N
  • Cluster memory and disk footprints slightly vary depending on number of nodes

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